Immediate postoperative outcomes after liver transplantation - a patient perspective to inform perioperative clinical trials (part of the REFIL research program)
- Logistics
- Virtual
- Anticipated time commitment
- 8-10 hours per patient
- Application deadline
- Type of Organ
- Liver
- Opportunity Type
- Focus Group
- Theme
- T5 - Restoring Long-Term Health
Liver transplantation (LT) is the only definitive treatment for end stage liver disease (ESLD). Although survival rates following LT have been steadily improving, approximately two-thirds of LT recipients suffer from a severe complication such as acute kidney injury. These complications have important implications for patient-centered outcomes, contributing to increased morbidity and mortality.
We are currently conducting a pilot randomized controlled trial to evaluate whether a multifaceted restrictive fluid management strategy during LT can improve clinical outcomes. However, it remains unclear which outcomes are considered the most important by lived experience experts.
Our main objective is to identify the clinical outcomes perceived as the most important by lived experience experts for a clinical trial investigating intraoperative fluid management strategies in LT.
We will conduct an electronic consensus development panel. We will involve between up to 8 lived experience experts. As such, we will involve LT recipients who bring valuable firsthand experience of the transplantation process. The consensus development panel will proceed in three steps:
- Summarizing the trial: participants will be presented with a summary of the trial, including the clinical outcomes identified by our research team.
- Outcome discussion: participants will discuss the clinical outcomes and suggest any additional patient-important outcomes that may be missing.
- Outcome ranking: participants will rank the clinical outcomes based on their perceived importance.
Findings from the consensus development panel will guide the selection of the primary and secondary outcomes for a large-scale, multicenter Canadian randomized controlled trial measuring the efficacy of restrictive fluid management strategies in LT.
This will ensure that the trial measures outcomes that matter to those directly experiencing LT.
Experience required
Experience with collaboration in research, so PFD may understand the importance of selecting meaningful outcomes in clinical research.
Potential roles for PFD Partners
- PFDs will be invited to participate (honorarium: 1h to review the document). At this time, they will receive a document (a lay summary, which we can expand upon with additional information from the summary you already sent to us) outlining the study's goal, details about the activity's conduct, and what we expect from their participation.
- Meeting #1 (2 hours long - 2h honorarium): Summarizing the trial - present the proposal, explain the current status, and outline the next steps.
- Meeting #2 (3h meeting - 3h honorarium) Outcome discussion and outcome ranking. PFDs will discuss the clinical outcomes and suggest any additional patient-important outcomes that may be missing. Last, participants will rank the clinical outcomes based on their perceived importance.
- Final revision on the patient-related outcomes outputs (2h of honorarium)
Total hours per PFD: 8 hours.
We are recruiting 6-8 liver transplant recipients.
Reimbursement
To be discussed
How to get in touch
- Name
- Manuel Escoto
- Job title
- CDTRP Staff
- mescoto@cdtrp.ca
Co-investigator of the project: Christian Vincelette