REFIL-2: Effects of an intraoperative low-splanchnic blood volume restrictive fluid management strategy compared to a cardiac output optimized liberal fluid management strategy on postoperative outcomes in liver transplantation: A multicenter randomized controlled trial
- Logistique
- Virtuel
- Durée prévue de l’engagement
- 10-20 hours per year
- Date limite de candidature
- Type d’organe
- Liver
- Type d’occasion
- Research Partner
- Thème
- T3 - Better Grafts
Liver transplant recipients often experience complications after surgery, which can delay recovery and affect quality of life. Currently, there is no clear consensus on the best way to manage fluid administration and blood pressure during surgery to reduce these risks.
This study aims to identify the approach that leads to fewer complications and better recovery.
The study will compare two commonly used intraoperative strategies during liver transplantation:
- A restrictive approach, involving the removal of a small amount of blood at the start of surgery and limited fluid administration, only when necessary
- A liberal approach, with no blood removal and more generous fluid administration Participants will be randomly assigned to one of these two approaches.
Outcomes have been selected in collaboration with patient partners and include severe postoperative complications, early recovery, quality of life at 6 and 12 months, survival up to one year, and healthcare resource use.
A total of 866 patients will be recruited across multiple centers in Canada and France.
This study will help identify the most effective intraoperative strategy to improve patient outcomes after liver transplantation. The results are expected to inform clinical guidelines and support more consistent, patient-centered care.
Expérience requise
Perioperative transplant care
Rôles potentiels pour les partenaires PFD
Patient partners will be actively involved throughout the study to ensure that the research reflects patient priorities and addresses outcomes that matter most to patients. They will contribute to:
- Interpretation of results, help guide how findings are communicated, and advise on the relevance of outcomes and follow-up measures.
- Patient partners may thus play a key role in ensuring that the findings are meaningful, accessible, and relevant to the broader patient community.
- The PFD partner could be part of the research team and the steering committee of the REFIL-2 program.
Remboursement
CDTRP recommended compensation of $50/hour. Final time committment to be agreed between research team, PFD partner, and CDTRP.
https://www.elipto.ca/refil